Side effects
Can the Wegovy pill lower your blood pressure?
The label reports low blood pressure in 1.3 percent of people on the drug against 0.4 percent on placebo, and fainting in 0.8 against 0.2 percent. It was more frequent in people already on blood pressure medicine, and often tied to fluid loss from stomach side effects.
The Oolite team, from the FDA labels
Sources checked Oct 27, 2026
Published Nov 3, 2026
Updated Oct 27, 2026 · 2 min read
The short answer
The label reports low blood pressure in 1.3 percent of people on the drug against 0.4 percent on placebo, and fainting in 0.8 against 0.2 percent. It was more frequent in people already on blood pressure medicine, and often tied to fluid loss from stomach side effects.
What the label says
The adverse reactions section (§6.1) has a paragraph called Hypotension and Syncope. Hypotension is low blood pressure, syncope is fainting. The paragraph sits under a heading that brings it to the tablet:
From the labelThe below adverse reactions were reported in WEGOVY injection clinical trials and are applicable to both WEGOVY injection and WEGOVY tablets.
So the numbers come from the injection trials in adults, and the label applies them to both forms. Then the paragraph itself:
From the labelAdverse reactions related to hypotension (hypotension, orthostatic hypotension, and decreased blood pressure) were reported in 1.3% of WEGOVY-treated adult patients versus 0.4% of placebo-treated patients …
The same sentence goes on to fainting: 0.8 percent on the drug against 0.2 percent on placebo, in the same trials.
Two sentences follow that say where it came from and who it touched most:
From the labelSome reactions were related to gastrointestinal adverse reactions and volume loss associated with WEGOVY.
From the labelHypotension and orthostatic hypotension were more frequently seen in patients on concomitant antihypertensive therapy.
Reading the numbers
Low blood pressure was uncommon: a little over one person in a hundred on the drug, against fewer than one in two hundred on placebo. Fainting was rarer still. The label does not say how large the drop was, only how often a reaction was reported.
Orthostatic hypotension is the drop that comes on standing up: the room tilts for a second when you get out of bed or off the sofa. Dizziness, which can come from it, is in the common side effect table: 8 percent on the injection against 4 percent on placebo, and the label says the tablet trial found similar types and frequencies.
The fluid link
The label ties some of these reactions to "volume loss", meaning fluid lost through vomiting or diarrhea. The Medication Guide says the same thing from the patient's side:
From the labelDiarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration.
It asks you to tell your healthcare provider right away about nausea, vomiting or diarrhea that does not go away.
If you take blood pressure medicine
That is the group the label says it was seen in more often. It also tested two common blood pressure medicines with semaglutide, in the pharmacokinetics section (§12.3): lisinopril and furosemide showed no clinically significant differences in how the body handled them. That is about drug levels, not about the combined effect on your pressure.
The label gives patients no instruction to change a blood pressure medicine. Readings, symptoms on standing, and any fainting go to the prescriber, who decides whether anything changes.
Oolite does not read blood pressure. Its journal keeps how the day felt, a dizzy morning or a day of vomiting, so the pattern is on paper at the appointment, next to your own readings.
Questions people ask
Do these figures apply to the tablet?
They come from the injection trials, and the label says that this group of adverse reactions is applicable to both Wegovy injection and Wegovy tablets.
I take lisinopril or furosemide. Does that change anything?
The label tested both with semaglutide and found no clinically significant difference in how the body handles them. It does say low blood pressure was seen more often in people on blood pressure medicine, so your prescriber may want to review your readings.
Should I lower my blood pressure medicine myself?
No. The label gives no instruction to patients on this. Any change to a blood pressure medicine is a decision for the prescriber, based on your readings over time.
I feel dizzy when I stand up. Is that this?
Dizziness is a common listed effect, reported by 8 percent on the drug against 4 percent on placebo in the injection trials. Orthostatic hypotension, a drop in pressure on standing, is one of the reactions the label counts. Tell your healthcare provider, and mention any fainting.
Sources
- Wegovy prescribing information, Novo Nordisk, §6.1 Hypotension and Syncope, revised 06/2026 · Hypotension 1.3 vs 0.4 percent, syncope 0.8 vs 0.2 percent in adults; some reactions related to GI adverse reactions and volume loss; more frequent with antihypertensive therapy; reactions applicable to both injection and tablets.
- Wegovy prescribing information, Novo Nordisk, §6.1 Table 3 and §12.3, revised 06/2026 · Dizziness 8 vs 4 percent with the 2.4 mg injection, tablet trial similar; no clinically significant pharmacokinetic differences with lisinopril or furosemide.
- Wegovy Medication Guide, Novo Nordisk, revised 06/2026 · Dehydration leading to kidney problems; drink fluids; tell your provider about nausea, vomiting or diarrhea that does not go away.
Sources checked Oct 27, 2026. This page is information, not medical advice: read the medical disclaimer, and talk to your prescriber or pharmacist about your own treatment.
Written by
The Oolite team, from the FDA labels
We make Oolite. Every answer starts from the FDA prescribing information, quoted word for word, and is rewritten when a label changes.
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